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Family Practice Vol. 13, No. 2, 138-143
© Oxford University Press 1996

research-article

Antihypertensive therapy in older patients with isolated systolic hypertension: the Syst-Eur experience in general practice

H Celis, Y Yodfat, L Thijs, D Clement, J Cozic, P De Cort, F Forette, M Grégoire, J Heyrman, G Stibbe, M Van den Haute, J Staessen, R Fagard on behalf of the Syst-Eur Investigators

Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde-Cardiologie UZ Gasthuisberg, Hercstraat 49, B-3000 Leuven, Belgium

BACKGROUND AND OBJECTIVE: This interim report from the Syst-Eur trial investigated the level of blood pressure control achieved during the double-blind period in patients followed in general practices.

METHODS: In the Syst-Eur trial elderly patients (60 years or older) with isolated systolic hypertension were randomized to either active or placebo treatment. Active treatment consisted of nitrendipine combined with enalapril and/or hydrochlorothiazide to reduce systolic pressure to < 150 mmHg and by ≥20 mmHg. Matching placebos were used in the control group.

RESULTS: This analysis was restricted to patients of general practitioners who had been followed for at least 12 months. The placebo (N = 204) and active treatment (N = 217) groups had similar characteristics at randomization. At one year, the difference in sitting pressure between the two treatment groups was 10 mmHg systolic and 4 mmHg diastolic. Fewer patients remained on monotherapy in the placebo than in the active treatment group and on placebo the second and third line medications were started earlier. Nitrendipine tablets were discontinued in 10 patients on placebo and in 21 patients assigned to active treatment (P < 0.001 for all comparisons).

CONCLUSIONS: A significant blood pressure reduction can be achieved and maintained in older patients with isolated systolic hypertension followed by general practitioners. Whether this blood pressure reduction results in a clinically meaningful decrease of cardiovascular complications is under investigation.

Keywords. Antihypertensive treatment, general practice, isolated systolic hypertension, randomized clinical trial.


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