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Family Practice Vol. 5, No. 1, 29-35
© Oxford University Press 1988

research-article

Aetiology of Acute Pharyngitis and Clinical Response to Empirical Therapy with Erythromycin Versus Amoxicillin

ROBERT M GUTHRIE, GARY E RUOFF*, BARRY A ROFMAN**, DAVID GINSBERG**, RONDA R KARP**, SHARON M BROWN{dagger} and GREGORY A SHULZ{dagger}{dagger}

Department of Family Medicine and Pharmacology. Ohio State University Columbus. Ohio. USA
*Westside Family Medical Center PC, Kalamazoo. MI. USA
**Harleysvillc Medical Associates PC, Harleysvillc, PA, USA
{dagger}Department of Pharmacology, Ohio State University Ohio. USA
{dagger}{dagger}Department of Clinical Development. Abbott Laboratories, Pharmaceutical Products Division Abbott Park. IL. USA

Reprint requests to Dr Guthrie, Department of Family Medicine. Ohio State University. 456 Clinic Drive, Columbus, Ohio 43210, USA.

Guthrie R M, Ruoff G E, Rofman BA, Ginsberg D, Karp R R, Brown S M and Schulz GA. Aetiology of acute pharyngitis and clinical response to empirical therapy with erythromycin versus amoxicillin. Family Practice 1988; 5: 29–35.

One hundred and eighty-nine adults with acute pharyngitis had culture and serological evaluation for groupA beta haemolytic streptococci (GABHS), Mycoplasma pneumoniae, and Branhamella catarrhalis. Sixteen patients had evidence for infection with GABHS, none for M. pneumoniae, and one for B. catarrhalis. For those with GABHS, there was no significant difference between empirical treatment by erythromycin or amoxicillin. For those without GABHS, empirical treatment with erythromycin appeared to result in a statistically significant reduction in cough and a noticeable but less than significant reduction of other symptoms when compared to empirical treatment with amoxicillin. The new formula tion of erythromycin utilized in this study (PCE) may be associated with a reduction in gastrointestinal intolerance from that reported with other erythromycin products.


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