Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Pesce, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pesce, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Family Practice Vol. 18, No. 4, 457-460
© Oxford University Press 2001

Selections from Current Literature

Colorectal cancer screening

Anthony Pesce

Department of Family Medicine, Health Sciences Center, L-4, SUNY at Stony Brook School of Medicine, Stony Brook, NY 11794, USA.

Pesce A. Colorectal cancer screening. Family Practice 2001; 18: 457–460.

Introduction

Colon cancer is the second leading cause of cancer deaths in the USA. Annually, ~129 000 new cases of colorectal cancer are diagnosed, with 59 000 associated deaths.1 It is widely believed that most colorectal cancers arise from adenomatous polyps. The probability of an adenomatous polyp becoming a cancer depends on the gross appearance of the lesion, its histological features and its size.2 Sessile (flat-based) polyps are more likely to develop into cancer than are pedunculated (stalked) lesions. Histologically, villous adenomas are more likely to develop into carcinoma than are tubular lesions. The main approach to colorectal cancer prevention is the detection and removal of pre-cancerous lesions (primary prevention). In addition, cancer found in its early stages may be more amenable to treatment (secondary prevention).

There have been no randomized controlled clinical trials suggesting that screening sigmoidoscopies decrease mortality, although other studies suggest this association. In one retrospective study, only . . . [Full Text of this Article]

Mandel JS et al. Colorectal cancer mortality: effectiveness of biennial screening for fecal occult blood. J Natl Cancer Inst 1999; 91: 434–437.
Comment. Mandel JS et al. The effect of fecal occult blood screening on the incidence of colorectal cancer. N Engl J Med 2000; 343: 1603–1607.
Comment. Levin TR et al. Predicting advanced proximal colonic neoplasia with screening sigmoidoscopy. J Am Med Assoc 1999; 281: 1611–1617.
Imperiale TF et al. Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med 2000; 343: 169–174.
Lieberman DA et al. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. N Engl J Med 2000; 343: 162–168.
Conclusion

References


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?