Family Practice Vol. 16, No. 2, 103-111
© Oxford University Press 1999
North of England evidence-based guideline development project: summary version of guidelines for the choice of antidepressants for depression in primary care
For the North of England Anti-depressant Guideline Development Group
Centre for Health Services Research, University of Newcastle upon Tyne and
a Centre for Health, University of York.
Prof. Martin Eccles, MD, FRCP, FRCGP, Professor of Clinical Effectiveness, Centre for Health Services Research, University of Newcastle upon Tyne, 21 Claremont Place, Newcastle upon Tyne NE2 4AA, UK.
Eccles M, Freemantle N and Mason J. North of England evidence-based guideline development project: summary version of guidelines for the choice of antidepressants for depression in primary care. Family Practice 1999; 16: 103–111.
Received 19 May 1998; Accepted 7 October 1998.
Keywords. Anti-depressants, depression, guidelines..
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Aim of these guidelines |
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The aim of these guidelines is to provide recommendations, evidence-based where possible, to guide primary health care professionals in their use of antidepressants in the treatment of adults with depression and for whom the agreed course of action is to prescribe an antidepressant. The relative efficacy and tolerability of the various groups of antidepressants is explored, as well as performance within groups of certain individual drugs of interest. This information is drawn together with evidence on safety and health service resource use to profile the costs and benefits of antidepressant choice. The development group assumes that health care professionals will use general medical knowledge and clinical judgement to apply guideline recommendations when managing individual patients. It is also assumed that health care professionals will note the information, contra- indications, interactions and side-effects contained in the British National Formulary.1 Recommendations may not be appropriate for use in all circumstances. The
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Depression caseload |
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Current patterns of use of antidepressants |
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Guideline recommendations |
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Evidence from trials |
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Efficacy of antidepressants
Drop-out from treatment
Effective doses of antidepressants
Second-line treatment
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Safety and cost-effectiveness |
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Toxicity and safety of antidepressants
Economics of antidepressants
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Further research |
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Acknowledgments |
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References |
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