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Family Practice Advance Access published online on March 3, 2006
Family Practice, doi:10.1093/fampra/cml001
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© The Author (2006). Published by Oxford University Press. All rights reserved.
Received August 3, 2005
Accepted January 30, 2006

Article

Persistence of upper respiratory tract infections in a cohort followed from childhood to adulthood

Maroeska M. Rovers 1 *, Walter A. F. Balemans 2, Elisabeth A. M. Sanders 3, Cornelis K. van der Ent 2, Gerhard A. Zielhuis 4, and Anne G. M. Schilder 5

1 Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, The Netherlands; Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands; Department of Otorhinolaryngology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands
2 Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands
3 Department of Pediatric Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands
4 Department of Epidemiology and Biostatistics, University Medical Centre Nijmegen, The Netherlands
5 Department of Otorhinolaryngology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, The Netherlands

* To whom correspondence should be addressed.
Maroeska M. Rovers, E-mail: M.Rovers{at}umcutrecht.nl


  Abstract

Objective. To assess (1) prevalences of recurrent URTIs (rURTIs) and relapsing/persistent rURTIs and associated medical consumption between 0 and 21 years of age and (2) whether rURTIs experienced in early life predispose to upper airway disease later in life.

Methods. A cohort of all children born in Nijmegen, The Netherlands, between September 1982 and September 1983, was assessed repeatedly from 2 to 21 years of age with questionnaires regarding infections of the upper respiratory tract (URTIs), use of antibiotics, ENT operations and known risk factors for URTIs.

Results. One hundred and sixty-one of the 693 cohort member (23%) suffered from relapsing rURTIs between 0 and 21 years of age, whereas only 7 (1%) suffered from persistent rURTIs throughout this period. Two hundred and six (30%) had used antibiotics more than once; and 220 (32%) had undergone at least one ENT operation. Of the 166 participants with rURTI between 8 and 21 years, 140 (84%) had had rURTI before.

Conclusions. rURTIs are highly prevalent throughout early life and associated medical consumption is substantial. The challenge therefore is to develop therapeutic/preventive strategies that will prevent rURTIs in the first years of life.

Keywords: Upper respiratory tract infections; cohort; antibiotics; ENT operations.
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